The Big Setup 10-3 is the 18th level of The Big Setup and the 168th level of Angry Birds overall. There is a Golden Egg in this level. See this page for more information about the Golden Egg.
Fire the first Big Brother slightly downward through the left side of the bridge. Launch the next Big Brother into the two pigs in the bottom-right of the bridge. This second shot is a bit challenging, but earns higher scores.